Wellness & Cosmetics Published on March 5, 2025

GHK-Cu: The Copper Peptide Star of Anti-Aging Serums

2 min read

GHK-Cu (glycyl-L-histidyl-L-lysine-copper) is one of the most studied and widely used peptides in anti-aging cosmetics.

WHAT IS GHK-Cu?

Discovered in the 1970s, this tripeptide naturally present in human plasma has a strong affinity for copper. Its concentration decreases with age: from 200 ng/mL at age 20 to 80 ng/mL at age 60.

DOCUMENTED MECHANISMS OF ACTION

Studies show that GHK-Cu:

Stimulates collagen and elastin production
Promotes healing and skin renewal
Offers antioxidant protection
Improves skin firmness and clarity
Reduces fine lines and photo-induced damage

2024 TRENDS

According to a review published in PMC in 2025, peptides have taken center stage in skincare formulations. GHK-Cu is now found in:

Premium anti-aging serums
Post-procedure repair creams
Eye contour treatments

USAGE TIPS

Peptides are not compatible with all ingredients. Acids (AHA, BHA) can break peptide bonds. Recommendation: use acids in the morning, peptides in the evening, or wait 30 minutes between applications.

Advanced technologies like nanotechnology are now improving the stability and efficacy of peptide formulations.