Thymosin Alpha-1 10mg — Talpha1 Th1/TLR immunomodulator

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10mg vialIncluded
Bacteriostatic waterAdd
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The vial alone cannot be used as is. One sealed vial of Thymosin Alpha-1 10mg, lyophilised, without individual labelling.

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Eau Bactériostatique

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Thymosin Alpha-1 10mg (Talpha1, thymalfasin) is an N-acetylated 28 amino acid polypeptide, the bioactive fragment of thymosin fraction 5 secreted by the thymus. Identified in the 1970s by Allan Goldstein's team, it is today the most studied thymic peptide in the immunology literature, to the point of having yielded a drug marketed as Zadaxin in over thirty countries as a reference immunomodulator.

This 10mg format is the reinforced format: it doubles the material of the standard 5mg vial, sized for demanding immunological research protocols or extended fractionated-dose explorations, without multiplying reconstitutions. A single HPLC >98% controlled batch to run a complete series of experiments with homogeneous material.

Unlike growth or tissue-repair peptides, Thymosin Alpha-1 targets a single system with remarkable precision: cellular immunity. It is the reference tool for studying T lymphocyte maturation, Th1/Th2 balance and dendritic cell response, making it a must-have in immunomodulation protocols and seasonal immune-stress models.

Science

01
Mechanism of action

Thymosin Alpha-1's mechanism of action relies on a coordinated activation of innate and adaptive immunity, which sets it apart from single-target immunostimulants.

Toll-like receptor activation. Talpha1 activates the TLR-2 and TLR-9 receptors on the surface of dendritic cells and monocytes. This binding triggers the MyD88 pathway then NF-kappaB translocation, leading to dendritic cell maturation and enhanced antigen presentation. It is the initiating event of the immunomodulatory cascade.

Th1 orientation and T lymphocyte maturation. Talpha1 promotes the differentiation of helper T lymphocytes toward the Th1 profile, with increased production of IL-2 and interferon gamma. It stimulates T lymphocyte maturation within the thymus, increases functional CD4+ and CD8+ populations and restores a favorable Th1/Th2 ratio in documented immunosuppression contexts.

NK activity and rebalancing. Beyond T lymphocytes, Talpha1 increases the cytotoxic activity of NK (natural killer) cells and modulates the production of pro- and anti-inflammatory cytokines, tending to rebalance a dysregulated immune system rather than over-stimulate it. This bidirectional modulation property is the peptide's pharmacological signature and explains its adjuvant use in varied clinical contexts.

Clinical data

02Clinical studies

Thymosin Alpha-1 has an exceptional clinical corpus for a peptide, accumulated over more than three decades.

Chronic viral hepatitis. This is thymalfasin's (Zadaxin) historical indication: numerous trials on chronic hepatitis B and C show improved virological response, alone or in combination with interferons, founding its approval in over thirty countries.

Vaccine adjuvant in the elderly. Several studies document an improved vaccine response (influenza, hepatitis B) in populations with weakened immunity, notably elderly subjects and hemodialysis patients, with increased post-vaccination antibody titers.

Sepsis and critical care. Clinical trials on severe sepsis (including Chinese multicenter studies) evaluated Talpha1 as a modulator of the immune response in immunoparalysis states, with signals on the restoration of lymphocyte populations.

Adjuvant oncology and recent data. The literature explores Talpha1 as a chemotherapy adjuvant (lymphocyte recovery, quality of life) and, more recently, its value in lymphocyte-exhaustion contexts of severe viral infections, where restoration of T lymphocyte counts has been observed.

These data, though numerous, retain methodological heterogeneity. Atlas Lab Thymosin Alpha-1 remains a research tool, without therapeutic status in the context of its sale.

No references yet for this peptide — search PubMed for associated scientific literature.

The listed studies are provided for documentation and research purposes only. They do not constitute a therapeutic indication nor a recommendation for human use. This product is strictly for laboratory use only (RUO).

Lab workflow

03
Research protocols

The Atlas Lab Thymosin Alpha-1 10mg vial is reconstituted with bacteriostatic water. For a comfortable working concentration, 2 ml of bacteriostatic water yields 5 mg/ml; 1 ml yields 10 mg/ml for protocols requiring a small draw volume. The 10mg format allows long series without opening a new batch.

Reference schemes. The thymalfasin literature classically uses repeated subcutaneous administrations, often twice weekly over several weeks in immunomodulation protocols, or daily in the acute phase of immune-stress models. Talpha1's half-life (about 2 hours) explains the use of regular administrations rather than a single dose. Precise fractioning depends on the research model.

Handling. Reconstitute gently, without vortexing, letting the solvent glide down the wall. The 28 amino acid sequence is more sensitive than short peptides: avoid heat and mechanical agitation, draw under aseptic conditions, and maintain the cold chain after reconstitution.

Parameters provided for in vitro and model research documentation. For research use only (RUO), no human, diagnostic or therapeutic use.

Reconstitution for this format (10 mg)Standard volumes used in laboratory settings

Water added	Concentration	Reading marker
1 ml	10 mg/ml	10 UI = 1 mg
2 ml	5 mg/ml	40 UI = 2 mg

The volume of water does not change the product, only its concentration. Introduce the water slowly along the vial wall, never directly onto the lyophilisate, then swirl without shaking. Markers given on a 1 ml syringe graduated in 100 units.

Asepsis

Disinfect surfaces and stoppers (70% alcohol).

Solvent

Draw the required volume of bacteriostatic water.

Introduction

Inject gently against the vial wall (avoid direct jet on powder).

Solubilization

Roll the vial gently. Do not shake vigorously (degradation risk).

Solution storageOnce reconstituted: 2-8°C (refrigerator).

WarningTheoretical tool for chemical handling. Does not constitute medical advice.

I open the dilution calculator

What is normal on arrivalThe observations that worry customers, and are not defects

The amount of powder looks tiny. A lyophilisate takes up a few millimetres at the bottom of the vial, sometimes just a translucent film. The stated weight is there.
The powder is compact, stuck to the wall or to the stopper. Transport moves the freeze-dried cake around. It changes nothing to reconstitution.
The vial carries no individual label. That is our standard packaging, not a downgraded vial.
After reconstitution, deposits or filaments appear. This is common, especially with small molecules. Let it settle and roll the vial between your palms, never shake it.
The parcel is plain. Nothing on the outside indicates the contents or the brand name.

What is not normal: a cracked vial, an uncrimped cap or a stopper that moves, powder that has liquefied or changed colour. In those specific cases, write to us with a photo and we take the vial back.

Handling

04Storage & handling

In lyophilized form, Thymosin Alpha-1 10mg is stored at -20°C, away from light, and remains stable for several months to several years. The dry powder tolerates a few days of room-temperature transport, but a quick return to the freezer on receipt is recommended for this polypeptide, longer than tetrapeptides.

After reconstitution, the solution must be kept at +2/+8°C (refrigerator) and used within a short period (a few weeks at most). Bacteriostatic water (0.9% benzyl alcohol) allows multiple draws from the same vial, matching the serial use of the 10mg format. Absolutely avoid freeze/thaw cycles of the solution, which degrade peptide integrity.

Each Atlas Lab batch is HPLC-tested at over 98% purity, vacuum lyophilized.

01What is the difference between Thymosin Alpha-1 and TB-500 (Thymosin Beta-4)?

These are two **totally different** peptides despite the shared name. **Thymosin Alpha-1** (28 amino acids) targets **immunity**: T lymphocyte maturation, dendritic cells, Th1/Th2 balance. **TB-500 / Beta-4** (43 amino acids) targets **tissue repair and cell migration** (actin, angiogenesis). Do not confuse them in a protocol.

02Why the 10mg format over the 5mg?

The **10mg** doubles the material: a single batch covers a complete series of long or fractionated-dose protocols, with homogeneous material and a better cost per milligram. The 5mg remains suited to a short or one-off test.

03How much water to reconstitute the 10mg vial?

**2 ml of bacteriostatic water** yields 5 mg/ml; **1 ml** yields 10 mg/ml for a small draw volume. Reconstitute gently without vortexing, draw under aseptic conditions, keep cold after reconstitution (long, more sensitive peptide).

04Is Thymosin Alpha-1 an approved drug?

The molecule (thymalfasin, Zadaxin) is **approved as a drug in over thirty countries** for certain indications (viral hepatitis, immune adjuvant). However, the Thymosin Alpha-1 sold by Atlas Lab is a **research reagent (RUO)**, without therapeutic status, intended only for in vitro and model studies.

05How does Thymosin Alpha-1 act on the immune system?

It activates the **TLR-2 and TLR-9** receptors of dendritic cells, orients T lymphocytes toward the **Th1** profile (IL-2 and interferon gamma production), stimulates T lymphocyte maturation and increases NK cell activity. Its hallmark is to **rebalance** a dysregulated immune system rather than over-stimulate it.

06How to store Thymosin Alpha-1?

Lyophilized: **-20°C away from light**. Reconstituted: **+2/+8°C**, to use within a few weeks, **without freeze/thaw cycles**. This 28 amino acid polypeptide is more sensitive than short peptides: a quick return to the freezer on receipt is advised.

Benchmark

Similar peptides

Thymosin Alpha-1 10mg vs 5mg. Same molecule, same purity. The 5mg suffices for a short test. The 10mg is the reinforced format for long or fractionated-dose protocols: a single batch covers a complete series, ensuring material homogeneity and a better cost per milligram. For sustained immunological research, the 10mg is the obvious choice.

Thymosin Alpha-1 vs Thymosin Beta-4 (TB-500). Frequent confusion, very different molecules. Talpha1 is a 28 amino acid thymic peptide targeting immunity (T lymphocyte maturation, dendritic cells). Beta-4 / TB-500 is a 43 amino acid peptide targeting cell migration and tissue repair (actin, angiogenesis). Opposite biological targets despite the shared name.

Thymosin Alpha-1 vs other peptide immunomodulators. Compared with single-action immunostimulants, Talpha1 stands out for its bidirectional modulation: it rebalances rather than over-activates, a rare and documented property that explains its extensive clinical corpus.

Thymosin Alpha-1 vs LL-37 / KPV. LL-37 and KPV target antimicrobial immunity and local inflammation more; Talpha1 acts upstream on T lymphocyte maturation and orientation. Complementary in a global immune approach.

Thymosin Alpha-1 10mg Immunity & Health

Immunity

01
Mechanism of action

02Clinical studies

03
Research protocols

Asepsis

Solvent

Introduction

Solubilization

04Storage & handling

Similar peptides

Immunity

Product information

Asepsis

Solvent

Introduction

Solubilization

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