Epithalon 50mg - 69 € | Antiedad

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Tu kit completo

Vial 50mgIncluido
Agua bacteriostáticaAñadir
Jeringas de 1 mlAñadir

El vial por sí solo no puede usarse tal cual. Un vial sellado de Epithalon 50mg, liofilizado, sin etiquetado individual.

No olvide lo imprescindible

Eau Bactériostatique

7,90 €

Seringue de précision 1ml 29Gx107,90 €

Lingettes alcool isopropylique 70%x103,90 €

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Epithalon 50mg (Epitalon, Epithalone, AEDG) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, the short, stabilized version of Epithalamin, the pineal gland extract isolated in the 1980s by Vladimir Khavinson's Russian school of gerontology. With a molecular weight of approximately 390 Da, this tetramer is today the most documented anti-aging peptide in the bioregulation literature, studied continuously for over three decades at the St. Petersburg Institute of Bioregulation and Gerontology.

This 50mg format is not just a vial: it is the long-cure format. Most Epithalon research protocols rely on short but repeated cycles (10 to 20 days, several times a year). Concentrating 50mg of material in a single HPLC >98% vial covers a full research cycle without multiplying reconstitutions, handling steps and contamination risks. It is the choice of serious, longitudinal protocols where batch consistency matters most.

Its scientific appeal rests on a target unique among peptides: telomerase, the enzyme that rebuilds chromosome ends. On this target, Epithalon has generated in vitro and animal data that few research molecules can claim, placing it at the heart of research on cellular senescence and the biological clock.

Science

01
Mecanismo de acción

Epithalon's mechanism of action is organized around three complementary axes that explain its reference status in aging research.

Telomerase activation. With each division, somatic cells lose a fraction of their telomeres, the protective caps at chromosome ends; once they reach the Hayflick limit, they enter senescence. Khavinson's work (2003) showed that Epithalon induces expression of the catalytic subunit of telomerase (hTERT) in human somatic fibroblasts, with measurable telomere elongation and resumption of divisions beyond the expected limit. This founding observation made the tetramer a major study molecule.

Restoration of the pineal axis and melatonin. Epithalon derives from the pineal gland and acts upon it. Russian studies document a normalization of the circadian melatonin rhythm in aged subjects, whose nocturnal secretion collapses with age. This restoration of the nocturnal peak underlies observations on deep sleep and circadian synchronization.

Modulation of gene expression. Khavinson's model proposes that short peptides penetrate the nucleus and interact directly with DNA promoter sequences, modulating the expression of genes linked to the cell cycle, repair and antioxidant defense. This concept of peptide epigenetic regulation remains central in the Russian bioregulation literature.

Clinical data

02Estudios clínicos

The Epithalon corpus is dense and longitudinal, a rare feature for a research peptide.

Telomerase and telomeres (Khavinson, 2003). Published in the Bulletin of Experimental Biology and Medicine, the seminal study showed induction of telomerase activity and telomere elongation in human fibroblasts, exceeding the Hayflick limit by more than ten additional divisions.

Animal longevity. Several rodent cohorts (CBA mice, rats) treated with Epithalon cycles show a reduction in spontaneous tumor incidence and an increase in maximum lifespan compared with controls, with normalization of oxidative stress markers. Anisimov and Khavinson published repeatedly on these models.

Longitudinal human study (Korkushko, 2011). A multi-year follow-up of elderly patients treated with Epithalon cycles: the authors report a reduction in mortality in the treated group versus control over a 6 to 12 year window, with restoration of the melatonin profile. It is one of the rare human survival datasets associated with a research peptide.

These results, mostly from the Russian school, remain to be confirmed by large independent randomized trials. Western literature remains cautious in the absence of large-scale replication. Epithalon is, to date, a research tool, not a validated therapeutic.

Todavía no hay referencias para este péptido: busque en PubMed la literatura científica asociada.

Los estudios enumerados se facilitan únicamente con fines documentales y de investigación. No constituyen una indicación terapéutica ni una recomendación de uso humano. Este producto es estrictamente de uso exclusivo en laboratorio (RUO).

Lab workflow

03
Protocolos de investigación

The Atlas Lab Epithalon 50mg vial is reconstituted with bacteriostatic water. For a comfortable working concentration, 2 ml of bacteriostatic water yields 25 mg/ml; 5 ml yields 10 mg/ml, a practical ratio for finely fractioning a long cycle. Volume choice depends on the fractioning targeted by the research protocol.

Reference cycle scheme. The Russian literature favors short repeated cycles rather than continuous administration: typically 10 to 20 consecutive days, two to three times a year. The rationale is that the effect on gene expression and telomerase persists after cessation, making continuous dosing unnecessary. The 50mg format is precisely calibrated to cover a full cycle from a single batch, ensuring material homogeneity throughout the experiment.

Handling. Reconstitute by letting the solvent run slowly down the vial wall, without violently shaking the tetramer. Never vortex. Draw under aseptic conditions. Epithalon's short sequence makes it robust, but handling rigor conditions inter-cycle reproducibility.

These parameters are provided for in vitro and model research documentation. For research use only (RUO), no human, diagnostic or therapeutic use.

Reconstitución para este formato (50 mg)Volúmenes estándar utilizados en laboratorio

Agua añadida	Concentración	Marca de lectura
2 ml	25 mg/ml	10 UI = 2,5 mg
3 ml	16,67 mg/ml	10 UI = 1,67 mg

El volumen de agua no cambia el producto, solo su concentración. Introduzca el agua despacio por la pared del vial, nunca directamente sobre el liofilizado, y luego gírelo suavemente sin agitar. Las marcas se dan sobre una jeringa de 1 ml graduada en 100 unidades.

Asepsia

Desinfecte las superficies y los tapones (alcohol al 70%).

Disolvente

Extraiga el volumen necesario de agua bacteriostática.

Introducción

Inyecte suavemente contra la pared del vial (evite el chorro directo sobre el polvo).

Solubilización

Haga rodar el vial suavemente. No lo agite con fuerza (riesgo de degradación).

Conservación de la soluciónUna vez reconstituido: 2-8°C (nevera).

AdvertenciaHerramienta teórica para manipulación química. No constituye un consejo médico.

Abro la calculadora de dilución

Lo que es normal al recibirloLas observaciones que inquietan a los clientes y no son defectos

La cantidad de polvo parece mínima. Un liofilizado ocupa unos pocos milímetros en el fondo del vial, a veces solo una película translúcida. El peso indicado está ahí.
El polvo está compacto, pegado a la pared o al tapón. El transporte desplaza la torta liofilizada. No cambia nada en la reconstitución.
El vial no lleva etiqueta individual. Es nuestro embalaje estándar, no un vial de menor calidad.
Tras la reconstitución aparecen depósitos o filamentos. Es habitual, sobre todo con moléculas pequeñas. Deje que se asiente y haga rodar el vial entre las palmas, nunca lo agite.
El paquete es neutro. Nada en el exterior indica el contenido ni el nombre de la marca.

Lo que no es normal: un vial agrietado, una cápsula sin engastar o un tapón que se mueve, polvo que se ha licuado o cambiado de color. En esos casos concretos, escríbanos con una foto y recuperamos el vial.

Handling

04Conservación y manipulación

In lyophilized form, Epithalon 50mg is remarkably stable: stored at -20°C, away from light, the tetramer keeps for several years without measurable degradation. On receipt, freezer storage is ideal; a few days at room temperature during transport does not affect the dry powder, as the short AEDG sequence is little sensitive to heat in solid state.

After reconstitution, keep the solution at +2/+8°C (refrigerator) and use it within the following weeks. Bacteriostatic water (0.9% benzyl alcohol) limits microbial proliferation and allows multiple draws from the same vial, which fits perfectly with the long-cycle use of the 50mg format. Avoid repeated freeze/thaw cycles of the reconstituted solution.

Each Atlas Lab batch is HPLC-tested at over 98% purity, vacuum lyophilized.

01Why choose the Epithalon 50mg format over the 10mg?

Because Epithalon protocols rely on **long, repeated cycles** (10 to 20 days, several times a year). The 50mg covers a full cycle from a single batch: no inter-vial variability over the experiment, fewer reconstitutions, and a much better cost per milligram. The 10mg remains relevant for a one-off test.

02How much bacteriostatic water to reconstitute the 50mg vial?

Depending on the targeted fractioning: **2 ml** gives a 25 mg/ml solution, **5 ml** gives 10 mg/ml (easier to finely fraction over a long cycle). Let the solvent run down the wall, never vortex, draw under aseptic conditions.

03Does Epithalon really activate telomerase?

Khavinson's work (2003) shows **in vitro** induction of telomerase (hTERT) and telomere elongation in human fibroblasts, exceeding the Hayflick limit. These data are robust in cellular and animal models but remain to be confirmed by independent randomized human trials. It is a research tool, not proof of an anti-aging effect in humans.

04How to store Epithalon?

Lyophilized: **-20°C away from light**, stable for several years. Reconstituted: **+2/+8°C**, to be used within the following weeks, without repeated freeze/thaw cycles. The dry powder tolerates room-temperature transport without issue.

05What is the difference between Epithalon and Epithalamin?

Epithalamin is the **natural extract** of the pineal gland isolated by the Russian school; Epithalon (AEDG, Ala-Glu-Asp-Gly) is the corresponding **synthetic tetrapeptide**, with a defined, reproducible sequence controllable by HPLC. Epithalon is the modern, pure, standardized version.

06Is Epithalon intended for human use?

No. Atlas Lab Epithalon is strictly for **research use only (RUO)**: in vitro and model studies. It is not intended for human, diagnostic or therapeutic use and does not have drug status.

Benchmark

Péptidos similares

Epithalon 50mg vs 10mg. Same molecule, same purity; the difference is strategic. The 10mg suits a one-off test or a mini-cycle. The 50mg is the format for longitudinal protocols: a single batch for a full cycle, hence zero inter-vial variability over the experiment, and a markedly better cost per milligram. For any serious senescence research, the 50mg is the rational choice.

Epithalon vs GHK-Cu. Two anti-aging references with distinct targets: Epithalon acts on telomerase and the pineal axis (biological clock, replicative senescence); GHK-Cu acts on the extracellular matrix and over 4000 tissue regeneration genes (skin, collagen). Complementary rather than competing.

Epithalon vs NAD+. NAD+ targets cellular energy metabolism and sirtuins; Epithalon targets telomere length and circadian rhythm. Two different levers of aging biology.

Epithalon vs non-peptide telomerase activators (TA-65 type). Epithalon is a short synthetic peptide with a defined sequence, verifiable by HPLC, whereas astragalus plant extracts show significant compositional variability. Molecular precision is the tetramer's argument.

Epithalon 50mg Antiedad

Longevidad

01
Mecanismo de acción

02Estudios clínicos

03
Protocolos de investigación

Asepsia

Disolvente

Introducción

Solubilización

04Conservación y manipulación

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Longevidad

Información del producto

Asepsia

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Introducción

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